MBBS(HK), MRCP(UK), FHKAM(Paediatrics), FRCP(Edinburgh), FHKCPaedClinical Associate Professor
Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine,The University of Hong Kong
Research interests
Neuroprotection against neonatal brain injuries
Neurodegeneration of motor neurons secondary to mutant androgen receptorwith polyglutamine expansion
IGF-I n human fetal and postnatal growth and neural protectionMolecular genetics of paediatric disorders
Current projectsNeonatal brain injuries and neuroprotection Main fields: Bilirubin toxicity and
hypoxic ischaemic encephalopathyStudying the protective role of IGF-I in neural
Studying the cellular and molecular mechanisms of p75 neurotrophic receptormediated apoptosis in HIE
Studying the regulation of interleukin-6 by bilirubin - promotor-reportergeneconstructStudying the molecular mechanisms of bilirubin-mediated cell death - focusingon mitochondrial dysfunction and
apoptosis in bilirubin induced apoptosisEvaluating the protective/therapeutic effects
of various treatment for neonatal
brain injuries - caspase inhibitors; IGF-I; neurotrophins; traditional Chinese
medicineNeurodegeneration mouse model Using transgenic mice and in vitro culture
models to study the mechanisms of neurodegeneration in a human hereditary
neurodegenerative disorder of motor neuron, spinal and bulbal muscular
atrophy, caused by trinucleotide CAG repeat expansion in the androgen
receptor geneMolecular genetics of endocrine disorders, neurodegenerative and
general
paediatric disorders